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No one knows precisely what causes fibromyalgia. Some possible triggers can sometimes include: Using two separate drugs to lose weight naturally can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the individuals who go through it one should err to the side of caution and allow FDA do its job and demand some investigation be done so that the public knows the side effects and risks of the medications before we take them. Keep in mind that drug companies have been in business to generate money and that they would say almost anything to keep people on their own medications. Researchers found that participants investing in this drug for the year, dropped excess weight within 4 weeks and have kept the extra weight off throughout the 56 weeks with the study. Contrave can be a combination from the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs that are made up of several active ingredient, that might make them far better and safer. Combo-pilling is the newest fad or also the newest in the future under scrutiny and therefore it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills has become popular is the fact that since right now there are no long term prescription weight loss supplements that have been authorized by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be approved by the FDA. Seizures can be a side effect with Contrave and really should not be taken in people who have seizure disorders. The drug could also raise blood pressure level and heartbeat, and mustn't be used in people who have a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug. The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must not used in patients with uncontrolled high blood pressure levels, as well as by you aren't heart-related and cerebrovascular (blood vessel dysfunction impacting your brain) disease. Patients having a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients to the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stopping smoking. An independent report published by Gant Daily in April also stated that naltrexone also works best for kleptomaniacs and gambling addicts, as well. Citing research from the University of Minnesota School of Medicine, Gant Daily reported how the drug creates kleptomaniacs and chronic gamblers in the same way with alcohol and opioid addicts'by blocking the consequences of endorphins, that the brain releases when experiencing craving or compulsions.